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KMID : 1009020220200040768
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Clinical Psychopharmacology and Neuroscience
2022 Volume.20 No. 4 p.768 ~ p.772
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Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1
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Lu Tsung-Hua
Lin Shih-Hsien
Tseng Huai-Hsuan
Yang Yen Kuang
Chiu Nan Tsing
Chen Po See
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Abstract
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Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear.
Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1.
Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD.
Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
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KEYWORD
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Bipolar disorder, Dopamine, Tomography, emission-computed, single-photon, Sleep
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